Potential for application of hydroxyapatite-based bone grafting materials in spine surgery

The expansion in the number of primary joint replacements worldwide is causing a rise revision due to bacterial infection. Revision surgery with cementless implants appears be beneficial for long-term outcome, and using antibiotic-impregnated bone grafts can control infection provide good implant support. Autologous graft s (autografts) areused fill defects impaction grafting spinal reconstruction. Because their superior osteoinductive ability, autograft sare considered “gold standard” these treatments. However, better cost-benefit ratio, allografts are also often used. In case limited donor availability autologous or allogeneic s, materials reasonable alternative adjunct. Bone combine based on different substances. Growth factors morphogenetic protein family recombinant proteins that specifically induce cartilage growth. One advantage they combined several antibiotics. Th e choice antibiotics should consider possible dose-dependent cellular pharmacological side effects at implantation site, as well antimicrobial efficacy. Thus, microbiologists, pharmacologists surgeons must decide together which combination more appropriate. active ingredient supplements drugs, characterised by effect (bone replacement function) secondary (prevention recolonization materials). Both functions clinically validated during registration process Class III medical device. Currently, only few products available market. this review, we existing hydroxyapatite-based potential use spine surgery.